GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UVM | cis | rs10935120 | 1 | rs4417907 | chr3:134291363 | ANAPC13 | chr3:134196547-134204865:- | 0.45 | 6.73 | 1.03E-8 | Height |
| UVM | cis | rs10935120 | 1 | rs4423809 | chr3:134300107 | ANAPC13 | chr3:134196547-134204865:- | -0.45 | -6.73 | 1.03E-8 | Height |
| UVM | cis | rs4074493 | 1 | rs4460622 | chr1:231173033 | FAM89A | chr1:231154704-231175995:- | 0.53 | 4.61 | 2.42E-5 | Carotid plaque burden (smoking interaction) |
| UVM | cis | rs9902453 | 1 | rs4465649 | chr17:28394747 | EFCAB5 | chr17:28256874-28435469:+ | -0.4 | -5.08 | 4.7E-6 | Coffee consumption (cups per day) |
| UVM | cis | rs9902453 | 1 | rs4465650 | chr17:28396721 | EFCAB5 | chr17:28256874-28435469:+ | 0.39 | 4.92 | 8.11E-6 | Coffee consumption (cups per day) |
| UVM | cis | rs9876781 | 1 | rs4490383 | chr3:48484683 | TREX1 | chr3:48501186-48509043:+ | -0.4 | -4.9 | 8.74E-6 | Longevity |
| UVM | cis | rs10935120 | 1 | rs4498009 | chr3:134198008 | ANAPC13 | chr3:134196547-134204865:- | 0.47 | 7.01 | 3.68E-9 | Height |
| UVM | cis | rs9902453 | 1 | rs4533340 | chr17:28277951 | EFCAB5 | chr17:28256874-28435469:+ | 0.39 | 4.9 | 8.89E-6 | Coffee consumption (cups per day) |
| UVM | cis | rs10935120 | 1 | rs4535272 | chr3:134299916 | ANAPC13 | chr3:134196547-134204865:- | -0.45 | -6.73 | 1.03E-8 | Height |
| UVM | cis | rs10935120 | 1 | rs4572812 | chr3:134291177 | ANAPC13 | chr3:134196547-134204865:- | -0.45 | -6.73 | 1.03E-8 | Height |
| UVM | cis | rs9902453 | 1 | rs4575590 | chr17:28361969 | EFCAB5 | chr17:28256874-28435469:+ | -0.4 | -5.08 | 4.7E-6 | Coffee consumption (cups per day) |
| UVM | cis | rs9902453 | 1 | rs4581755 | chr17:28427898 | EFCAB5 | chr17:28256874-28435469:+ | 0.4 | 4.97 | 6.82E-6 | Coffee consumption (cups per day) |
| UVM | cis | rs8135828 | 1 | rs458196 | chr22:29978026 | CABP7 | chr22:30116344-30127818:+ | 1.03 | 6.84 | 6.87E-9 | Lipid traits |
| UVM | cis | rs11190604 | 1 | rs4604805 | chr10:102261409 | SEC31B | chr10:102246403-102289636:- | -0.39 | -5.1 | 4.38E-6 | Palmitoleic acid (16:1n-7) plasma levels |
| UVM | cis | rs703842 | 1 | rs4646536 | chr12:58157988 | TSFM | chr12:58176536-58191367:+ | -0.57 | -5.04 | 5.32E-6 | Multiple sclerosis |